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Authors
Affiliations
1 S.K.B College of Pharmacy, New Kamptee, Nagpur, M.S., IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 8 (2011), Pagination: 1231-1234
Abstract
A simple, sensitive, specific, spectrophotometric methods developed for the detection of Levocloperastine fendizoate (LCP) in bulk drug and pharmaceutical formulation. The λ max of the LCP was found to be 350nm. The method shows high sensitivity with linearity range of 2 to 10 μg/ml. Absorptivity value of LCP were found to be 395.93. In AUC method, The lower limit of detection and the limit of quantification was found to be 1.012 and 3.036 respectively. All the calibration curves shows a linear relationship between the absorbance and concentration and coefficient correlation was higher than 0.99. The regression of the curve was Y =0.039x - 0.001. Precision of the method was found to be 1.2057±0.01214 against the label claim of 708mg/100ml. The percentage recovery was found to be 99.752±0.6653. The proposed method will be suitable for the analysis of LCP in bulk and pharmaceutical formulation.
Keywords
Levocloperastine Fendizoate, Spectrophotometry, Beer's Law, Absorptivity Value and Area under Curve Method.
